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Statins May Up Breast Cancer–Specific and Overall Survival | 03:10 |
| Statins May Up Breast Cancer–Specific and Overall Survival Pam Harrison December 08, 2017 AN ANTONIO — Overall survival and, more intriguingly, breast cancer–specific survival are significantly enhanced by statin therapy when used both in the prediagnostic and the postdiagnostic setting compared with no statin use, suggests a Swedish nationwide study reported here at the San Antonio Breast Cancer Symposium (SABCS) 2017. "I don't think any of us were surprised that it was beneficial for women to be on a statin in terms of overall survival because statins have a lot of beneficial effects on cardiovascular disease prevention," lead investigator, Signe Borgquist, MD, PhD, professor of oncology, Aarhus University Hospital, Denmark, told Medscape Medical News. "But when we look at breast cancer–related death, which is a more interesting endpoint than overall survival when it comes to treatment as exposure, we see that both prediagnostic use and postdiagnostic use is beneficial for women in terms of breast cancer–related death, where we saw significantly lower hazard ratios if women were using a statin in either setting. If women were regular users, they had more benefit than if they were not regular users," she added. Data were collected from a nationwide retrospective cohort study involving 20,559 Swedish women diagnosed with breast cancer from July 2005 through 2008. Statin use was identified through the Swedish Prescription Registry, while breast cancer–specific death was identified from the national cause-of-death registry through the end of 2012. "During follow-up, a total of 4678 patients died, whereof 2669 were considered breast cancer–specific deaths," the investigators observed. Compared with women not receiving statins at all, women who took a statin regularly before their diagnosis had a 23% lower relative risk of dying from breast cancer (hazard ratio [HR], 0.77; P = .014). After their diagnosis, women who had been exposed to any statin use had a 17% lower relative risk of dying from breast cancer (HR, 0.83; P = .001). The benefit of taking a statin before diagnosis also did not seem to be influenced by the statin dose, Dr Borgquist added. For example, women who took an intermediate statin dose had a 26% lower relative risk for a breast cancer–related death (HR, 0.74; P = .019). In comparison, women who took high-dose statin therapy before diagnosis had a 16% lower risk of reaching the same endpoint, she added. Nor did the type of statin taken in the postdiagnostic setting affect the risk of dying from breast cancer: The relative risk was identical at an HR of 0.93 for both statin types (P < .001 and P = .002 for lipophilic and hydrophilic statins, respectively). "The main take-home message from this study is that all the Scandinavian studies are showing more or less the same beneficial effect in breast cancer, even though studies from the United Kingdom have not depicted as good an effect as we have," Dr Borgquist observed. What we would like to do now is conduct a large adjuvant trial to show that this holds true in a trial setting, which would hopefully enable us to identify robust predictive markers as to which women might benefit from a statin and which might not, because I am sure that not all breast tumors are equally susceptible to statin treatment," she added. HMG-CoA Reductase Target As Dr Borgquist explained, extrahepatic function of the statins may affect the mevalonate pathway in cancer cells by targeting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. "HMG-CoA reductase is differentially expressed in breast tumors," she noted, with some tumors having high levels of HMG-CoA reductase expression and others, much lower levels of expression. In early clinical work, Swedish investigators observed that high levels of HMG-CoA reductase expression was associated with better outcomes in breast cancer. | |
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